Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2389170 | 0.82 | NR1H2 (0.53) | BRD4NR1H2NR1H3RXRAALDH1A1 | |
| SCHEMBL2389121 | 0.75 | NR1H2 (0.62) | NR1H2NR1H3RXRAALDH1A1KMT2A | |
| SCHEMBL2388491 | 0.69 | NR1H2 (0.73) | BRD4NR1H2NR1H3RXRAALDH1A1 | |
| SCHEMBL2390575 | 0.68 | RXRA (0.53) | NR1H2NR1H3RXRAALDH1A1KMT2A | |
| SCHEMBL4902462 | 0.68 | RXRA (0.46) | BRD4NR1H2NR1H3RXRA | |
| SCHEMBL2390389 | 0.66 | RXRA (0.55) | BRD4NR1H2NR1H3RXRAALDH1A1 | |
| SCHEMBL2390970 | 0.66 | NR1H2 (0.65) | BRD4NR1H2NR1H3RXRAALDH1A1 | |
| SCHEMBL4904383 | 0.65 | RXRA (0.54) | BRD4NR1H2NR1H3RXRA | |
| SCHEMBL2388571 | 0.65 | RXRA (0.53) | BRD4NR1H2NR1H3RXRA | |
| SCHEMBL4904380 | 0.64 | RXRA (0.52) | BRD4NR1H2NR1H3RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |