Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | CCR3 | P51677 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.55 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5202473 | 0.85 | HRH3 (1.00) | HRH3ALDH1A1CCR3GAASMN1; SMN2 | |
| SCHEMBL5210254 | 0.83 | HRH3 (0.68) | HRH3GAASMN1; SMN2 | |
| SCHEMBL13463052 | 0.82 | HRH3 (0.70) | HRH3GAASMN1; SMN2SIGMAR1 | |
| SCHEMBL360084 | 0.82 | KCNH2 (0.77) | ALDH1A1CCR3KCNH2TMEM97SIGMAR1 | |
| SCHEMBL7173537 | 0.82 | HRH3 (0.61) | HRH3GAASMN1; SMN2KCNH2 | |
| SCHEMBL5598306 | 0.82 | HRH3 (0.73) | HRH3ALDH1A1CCR3GAASMN1; SMN2 | |
| SCHEMBL20328148 | 0.81 | CARM1 (0.70) | HRH3GAASMN1; SMN2PRMT6 | |
| SCHEMBL5202949 | 0.81 | HRH3 (0.70) | HRH3GAASMN1; SMN2KCNH2 | |
| SCHEMBL7179085 | 0.80 | HRH3 (0.62) | HRH3GAASMN1; SMN2KCNH2PRMT6 | |
| SCHEMBL8393625 | 0.80 | HRH3 (0.71) | HRH3ALDH1A1GAASMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241778-B2 | Non-imidazole aryloxypiperidines | ORTHO MCNEIL PHARMACEUTICAL, INC (US) | 2007-07-10 | — | — | US | claimed |