SCHEMBL5598277

SCHEMBL5598277

CC(C)COC(=O)N1CCN(c2cccc(-c3cc(C(F)(F)F)c(C#N)c(=O)n3Cc3ccc(F)cc3F)c2)CC1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
RXRA P19793 3/20 0.53
NR1H2 P55055 3/20 0.53
NR1H3 Q13133 3/20 0.53
KCNK3 O14649 6/20 0.39
ALDH1A1 P00352 3/20 0.38
HSD11B1 P28845 1/20 0.36
LMNA P02545 2/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
TSHR P16473 1/20 0.36
CASP1 P29466 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
MAPK1 P28482 1/20 0.36
RAB9A P51151 1/20 0.36
CHRM4 P08173 3/20 0.35
RORC P51449 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2390170 0.89 RXRA (0.55) RXRANR1H2NR1H3KCNK3ALDH1A1
SCHEMBL2390323 0.83 RXRA (0.62) RXRANR1H2NR1H3KCNK3HSD11B1
SCHEMBL2386325 0.81 RXRA (0.59) RXRANR1H2NR1H3ALDH1A1LMNA
SCHEMBL2263492 0.76 RXRA (0.68) RXRANR1H2NR1H3KCNK3ALDH1A1
SCHEMBL14214340 0.76 RXRA (0.75) RXRANR1H2NR1H3KCNK3ALDH1A1
SCHEMBL2387401 0.76 RXRA (0.62) RXRANR1H2NR1H3KCNK3ALDH1A1
SCHEMBL2389435 0.75 RXRA (0.57) RXRANR1H2NR1H3KCNK3ALDH1A1
SCHEMBL2262731 0.75 RXRA (0.83) RXRANR1H2NR1H3ALDH1A1MAPT
SCHEMBL2392079 0.75 RXRA (0.66) RXRANR1H2NR1H3KCNK3ALDH1A1
SCHEMBL2392062 0.75 RXRA (0.63) RXRANR1H2NR1H3KCNK3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1773337-A2 MODULATORS OF NUCLEAR RECEPTORS Exelixis, Inc. (US) 2007-04-18 EP disclosed
WO-2006025979-A9 MODULATORS OF NUCLEAR RECEPTORS EXELIXIS INC (US) 2006-04-20 WO disclosed
WO-2006025979-A2 MODULATORS OF NUCLEAR RECEPTORS EXELIXIS, INC. (US) 2006-03-09 WO disclosed