Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 3/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14382045 | 1.00 | TLR4 (0.46) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL10837113 | 1.00 | TLR4 (0.46) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL5599141 | 1.00 | TLR4 (0.46) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6457520 | 0.98 | TLR4 (0.45) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6457523 | 0.98 | TLR4 (0.45) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6465165 | 0.98 | TLR4 (0.45) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6458413 | 0.92 | TLR4 (0.51) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6452598 | 0.92 | TLR4 (0.51) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6452593 | 0.92 | TLR4 (0.51) | TLR4OPRM1OPRL1ALDH1A1KMT2A | |
| SCHEMBL6458424 | 0.92 | TLR4 (0.51) | TLR4OPRM1OPRL1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581469-B1 | METHOD FOR PRODUCING 2,6-SUBSTITUTED TRANS DECALIN DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-10-21 | — | — | EP | disclosed |
| US-7276633-B2 | Method for production naphthalene derivatives | MERCK PATENT GMBH (DE) | 2007-10-02 | — | — | US | disclosed |
| US-20060025615-A1 | Method for production naphthalene derivatives | MERCK PATENT GMBH (DE) | 2006-02-02 | — | — | US | disclosed |
| EP-1581469-A1 | METHOD FOR PRODUCING NAPHTHALENE DERIVATIVES | MERCK PATENT GmbH (DE) | 2005-10-05 | — | — | EP | disclosed |
| US-6913797-B1 | Decahydronaphthalene derivative | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2005-07-05 | — | — | US | disclosed |
| WO-2004050594-A1 | METHOD FOR PRODUCING NAPHTHALENE DERIVATIVES | MERCK PATENT GMBH (DE) | 2004-06-17 | — | — | WO | disclosed |
| EP-1108700-A1 | DECAHYDRONAPHTHALENE DERIVATIVE | DAINIPPON INK AND CHEMICALS, INC. (JP) | 2001-06-20 | — | — | EP | disclosed |
| US-4600528-A | Decalin-carbonitriles | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025615-A1 | Method for production naphthalene derivatives | AOX1, AOC3, CBR3 | TLR4 4436/4885OPRM1 338/4885OPRL1 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.