Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 2/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.31 |
| ▸ | CDK9 | P50750 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 5/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5602537 | 0.88 | LRRK2 (0.31) | LRRK2MGAMGAASIMGAM2 | |
| Hydrochloric Acid SCHEMBL5602758 | 0.81 | LRRK2 (0.36) | LRRK2MAPK8MAPK9MAPK10MGAM | |
| Hydrochloric Acid SCHEMBL5603035 | 0.81 | LRRK2 (0.36) | LRRK2MAPK8MAPK9MAPK10MGAM | |
| Hydrochloric Acid SCHEMBL5601675 | 0.80 | LRRK2 (0.32) | LRRK2MAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL5600777 | 0.79 | LRRK2 (0.31) | LRRK2MAPK8MAPK9MAPK10CYP11B1 | |
| Hydrochloric Acid SCHEMBL5602693 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL5603314 | 0.79 | LRRK2 (0.31) | LRRK2 | |
| Hydrochloric Acid SCHEMBL5600917 | 0.79 | LRRK2 (0.33) | LRRK2MGAMGAASIMGAM2 | |
| SCHEMBL5602767 | 0.77 | MGAM (0.35) | LRRK2MAPK8MAPK9MAPK10MGAM | |
| SCHEMBL5603041 | 0.77 | RECQL (0.34) | LRRK2MAPK8MAPK9MAPK10MGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7276567-B2 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2007-10-02 | — | — | US | disclosed |
| US-20050261449-A1 | Heterocyclic substituted metallocene compounds for olefin polymerization | EXXONMOBIL CHEMICAL PATENT INC. | 2005-11-24 | — | — | US | disclosed |