Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2850274 | 0.84 | KAT6A (0.49) | POLBKMT2AMEN1RENALDH1A1 | |
| SCHEMBL2850273 | 0.84 | KAT6A (0.49) | POLBKMT2AMEN1RENALDH1A1 | |
| SCHEMBL2847273 | 0.83 | POLB (0.47) | POLBKMT2AMEN1ALDH1A1KDM2B | |
| SCHEMBL4972565 | 0.82 | POLB (0.48) | POLBKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL4972119 | 0.78 | HRH2 (0.47) | POLBKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL5592323 | 0.77 | POLB (0.42) | POLBKMT2AMEN1RENALDH1A1 | |
| SCHEMBL3123201 | 0.76 | USP30 (0.47) | POLBKMT2AMEN1RENALDH1A1 | |
| SCHEMBL3123197 | 0.76 | USP30 (0.47) | POLBKMT2AMEN1RENALDH1A1 | |
| SCHEMBL276588 | 0.76 | KMT2A (0.57) | POLBKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL2846275 | 0.75 | POLB (0.45) | POLBKMT2AMEN1RENALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007117560-A2 | PIPERIDINE AND MORPHOLINE RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |