SCHEMBL5604353

SCHEMBL5604353

NN=Cc1cccc(CN2CC[C@@H](C(N)=O)C2=O)c1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
F10 P00742 18/20 0.38
PLG P00747 1/20 0.38
PROC P04070 1/20 0.38
F2 P00734 6/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6049829 0.83 MAPT (0.36) F10PLGPROCF2
SCHEMBL7413862 0.81 KCNH2 (0.37) F10PLGPROCF2
SCHEMBL27477777 0.81 PRMT6 (0.49) F10PLGPROCF2
Trifluoroacetic Acid SCHEMBL8834439 0.80 F10 (0.35) F10PLGPROCF2
Trifluoroacetic Acid SCHEMBL2329902 0.80 F10 (0.35) F10PLGPROCF2
Trifluoroacetic Acid SCHEMBL7421271 0.80 F10 (0.35) F10PLGPROCF2
SCHEMBL7829097 0.79 HDAC1 (0.49)
Trifluoroacetic Acid SCHEMBL7423282 0.78 HRH2 (0.35) F10PLGPROCF2
SCHEMBL7413859 0.78 F10 (0.56) F10PLGPROCF2
SCHEMBL7419118 0.77 SIRT2 (0.55)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1363668-B1 COMBINATIONS OF BILE ACID SEQUESTRANT(S) AND STEROL ABSORPTION INHIBITOR(S) AND TREATMENTS FOR VASCULAR INDICATIONS SCHERING CORP (US) 2007-08-15 EP claimed