Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.70 |
| ▸ | KLKB1 | P03952 | 7/20 | 0.69 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.69 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.69 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.69 |
| ▸ | F7 | P08709 | 3/20 | 0.69 |
| ▸ | F10 | P00742 | 2/20 | 0.69 |
| ▸ | F12 | P00748 | 2/20 | 0.69 |
| ▸ | PLG | P00747 | 1/20 | 0.69 |
| ▸ | KLK1 | P06870 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13650879 | 1.00 | F11 (0.70) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL13524462 | 0.85 | F11 (0.79) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL8239096 | 0.85 | F11 (0.76) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL13657381 | 0.84 | F11 (0.51) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL4138626 | 0.84 | F11 (0.61) | F11KLKB1 | |
| SCHEMBL4138623 | 0.84 | F11 (0.61) | F11KLKB1 | |
| SCHEMBL13524458 | 0.83 | F11 (0.80) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL13524465 | 0.83 | F11 (1.00) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL13524467 | 0.83 | F11 (1.00) | F11KLKB1PRSS1PRSS2PRSS3 | |
| SCHEMBL13524408 | 0.83 | F11 (1.00) | F11KLKB1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007070816-A2 | THIOPHENE DERIVATIVES AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-21 | — | — | WO | claimed |