SCHEMBL5604920

SCHEMBL5604920

c1ccc2cc(CNCCCN3CCNCC3)ccc2c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 3/20 0.64
MC4R P32245 3/20 0.56
MC5R P33032 3/20 0.56
MC3R P41968 2/20 0.56
MC1R Q01726 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
SLC6A2 P23975 1/20 0.48
SLC6A3 Q01959 1/20 0.48
KCNH2 Q12809 1/20 0.48
SIGMAR1 Q99720 2/20 0.48
HDAC3 O15379 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HRH3 Q9Y5N1 1/20 0.47
NPY1R P25929 1/20 0.46
NPY5R Q15761 1/20 0.46
ALDH1A1 P00352 1/20 0.46
ALOX15 P16050 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2472733 0.90 MC4R (0.63) MC4RMC5RMC3RMC1RSIGMAR1
SCHEMBL9522256 0.82 SLC6A4 (0.83) SLC6A4MC4RSLC6A2SLC6A3KCNH2
SCHEMBL5595495 0.81 CYP3A4 (0.55) CYP3A4CYP2D6SIGMAR1HDAC1ALDH1A1
SCHEMBL7383850 0.81 MC4R (0.55) MC4RMC5RMC3RMC1RSIGMAR1
SCHEMBL7390289 0.81 MC4R (0.55) MC4RMC5RMC3RMC1RSIGMAR1
SCHEMBL5595232 0.79 CYP3A4 (0.47) SLC6A4CYP3A4CYP2D6SIGMAR1ALDH1A1
SCHEMBL7468937 0.79 SLC6A2 (0.64) SLC6A4SLC6A2SIGMAR1
SCHEMBL5595933 0.79 TSHR (0.46) SLC6A4CYP3A4CYP2D6SIGMAR1HRH3
SCHEMBL8671948 0.79 SLC6A4 (1.00) SLC6A4MC4RSLC6A2SLC6A3KCNH2
SCHEMBL5595644 0.78 CYP3A4 (0.57) SLC6A4CYP3A4CYP2D6SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1809288-A1 USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2007-07-25 EP disclosed
WO-2006051489-A1 USE OF 1,4-BIS (3-AMINOALKYL) PIPERAZINE DERIVATIVES IN THE TREATMENT OF NEURODEGENERATIVE DISEASES INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2006-05-18 WO disclosed