Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.83 |
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | MC4R | P32245 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.47 |
| ▸ | HTR3B | O95264 | 1/20 | 0.47 |
| ▸ | HTR3A | P46098 | 1/20 | 0.47 |
| ▸ | HTR5A | P47898 | 1/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8671948 | 0.91 | SLC6A4 (1.00) | SLC6A4SIGMAR1SLC6A2SLC6A3KCNH2 | |
| Hydrochloric Acid SCHEMBL17444691 | 0.89 | SLC6A4 (0.97) | SLC6A4SIGMAR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL5604920 | 0.82 | SLC6A4 (0.64) | SLC6A4SIGMAR1SLC6A2SLC6A3KCNH2 | |
| SCHEMBL593143 | 0.81 | SLC6A4 (0.71) | SLC6A4SIGMAR1HRH3MC4RPKM | |
| SCHEMBL457139 | 0.80 | SIGMAR1 (1.00) | SIGMAR1LTA4H | |
| SCHEMBL10677264 | 0.80 | SIGMAR1 (1.00) | SIGMAR1LTA4H | |
| SCHEMBL16830448 | 0.80 | SLC6A4 (0.69) | SLC6A4SIGMAR1HRH3MC4RPKM | |
| SCHEMBL9372748 | 0.79 | SIGMAR1 (1.00) | SIGMAR1KCNH2HRH3 | |
| SCHEMBL20676401 | 0.79 | SIGMAR1 (0.96) | SIGMAR1LTA4H | |
| Hydrochloric Acid SCHEMBL7554612 | 0.79 | SIGMAR1 (0.96) | SIGMAR1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | claimed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | claimed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | claimed |