Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 8/20 | 0.71 |
| ▸ | CA2 | P00918 | 8/20 | 0.71 |
| ▸ | CA9 | Q16790 | 7/20 | 0.71 |
| ▸ | CA12 | O43570 | 5/20 | 0.71 |
| ▸ | CASP3 | P42574 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA4 | P22748 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | CLTC | Q00610 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1179176 | 0.85 | CA1 (0.73) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL31709781 | 0.85 | CA1 (0.73) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL17946666 | 0.84 | CASP3 (0.61) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL7837471 | 0.83 | CA1 (1.00) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL27840845 | 0.82 | CASP3 (0.79) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL30472950 | 0.82 | CASP3 (0.85) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL326305 | 0.82 | CASP3 (0.85) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL15486311 | 0.81 | CA1 (0.68) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL28611590 | 0.80 | CA1 (0.66) | CA1CA2CA9CA12CASP3 | |
| SCHEMBL2570317 | 0.79 | CASP3 (0.73) | CA1CA2CA9CA12CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
| WO-2007001932-A2 | SUBSTITUTED ISOTHIAZOLONES AS INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-04 | — | — | WO | disclosed |
| US-20060293374-A1 | Substituted isothiazolones | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293374-A1 | Substituted isothiazolones | LTB4R2, PTGES2, CYSLTR2 | CA1 4105/4885CA2 2665/4885CA9 4553/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.