Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Perflubutane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 8/20 | 0.48 |
| ▸ | CA1 | P00915 | 7/20 | 0.48 |
| ▸ | MMP1 | P03956 | 3/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.48 |
| ▸ | MMP9 | P14780 | 3/20 | 0.48 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | MMP13 | P45452 | 3/20 | 0.48 |
| ▸ | F2 | P00734 | 4/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Perflubutane SCHEMBL1302826 | 1.00 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL1303188 | 0.97 | CA2 (0.50) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL19739067 | 0.93 | CA2 (0.50) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL7865493 | 0.93 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL19739058 | 0.90 | CA2 (0.55) | CA2CA1MMP1MMP2MMP9 | |
| Potassium Ion SCHEMBL2497074 | 0.84 | CA2 (0.42) | CA2CA1MMP1MMP2MMP9 | |
| Potassium Ion SCHEMBL2500518 | 0.82 | CA2 (0.44) | CA2CA1MMP1MMP2MMP9 | |
| Potassium Ion SCHEMBL126340 | 0.82 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| Sulfuric Acid SCHEMBL29155809 | 0.81 | CA1 (0.38) | CA2CA1CA7CA13 | |
| Potassium Ion SCHEMBL2499164 | 0.80 | CA2 (0.39) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349893-B1 | FLAME RETARDANT POLYCARBONATE RESIN/ABS GRAFT COPOLYMER BLENDS | GEN ELECTRIC (US) | 2007-04-18 | — | — | EP | disclosed |
| EP-1349893-A2 | FLAME RETARDANT POLYCARBONATE RESIN/ABS GRAFT COPOLYMER BLENDS | GENERAL ELECTRIC COMPANY (US) | 2003-10-08 | — | — | EP | disclosed |
| US-6605659-B2 | Aromatic polycarbonate, rubber modified graft copolymer having a discontinuous rubber phase dispersed in continuous rigid thermoplastic phase, and the group 1A or 2A salt of an aromatic sulfonic acid as flame retardant; moldings | GENERAL ELECTRIC COMPANY | 2003-08-12 | — | — | US | disclosed |
| US-20020120044-A1 | Flame retardant polycarbonate resin/ABS graft copolymer blends | GENERAL ELECTRIC COMPANY | 2002-08-29 | — | — | US | disclosed |
| WO-2002050185-A2 | FLAME RETARDANT POLYCARBONATE RESIN/ABS GRAFT COPOLYMER BLENDS | GENERAL ELECTRIC COMPANY (US) | 2002-06-27 | — | — | WO | disclosed |