Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | HTR1A | P08908 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | DRD2 | P14416 | 1/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | HTR2B | P41595 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piribedil SCHEMBL29359749 | 1.00 | MEN1 (1.00) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL150101 | 1.00 | MEN1 (1.00) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL27036877 | 0.99 | MEN1 (0.97) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL14973600 | 0.99 | MEN1 (0.97) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL3765569 | 0.99 | MEN1 (0.97) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL28260221 | 0.94 | MEN1 (0.88) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL23652830 | 0.92 | MEN1 (0.85) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL1652330 | 0.91 | MAPK1 (0.82) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL1320656 | 0.90 | LMNA (1.00) | MEN1KMT2AUSP2CYP1A2CYP3A4 | |
| Piribedil SCHEMBL1320658 | 0.90 | LMNA (1.00) | MEN1KMT2AUSP2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3137065-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | Pharnext (FR) | 2017-03-08 | — | — | EP | disclosed |
| WO-2015165948-A2 | COMPOSITIONS, METHODS AND USES FOR THE TREATMENT OF DIABETIC NEUROPATHIES | PHARNEXT (FR) | 2015-11-05 | — | — | WO | disclosed |
| EP-1742624-A2 | DOPAMINE-AGONIST COMBINATION THERAPY WITH SEDATIVES FOR IMPROVING SLEEP QUALITY | Sepracor, Inc. (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005079851-A2 | DOPAMINE-AGONIST COMBINATION THERAPY WITH SEDATIVES FOR IMPROVING SLEEP QUALITY | SEPRACOR, INC. (US) | 2005-09-01 | — | — | WO | disclosed |