Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5605407 | 0.90 | AQP1 (0.47) | AQP1LMNATP53HTTEZH2 | |
| SCHEMBL5605912 | 0.85 | AQP1 (0.35) | AQP1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL6048001 | 0.82 | S1PR4 (0.35) | AQP1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL4766477 | 0.81 | AQP1 (0.39) | AQP1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL4766472 | 0.80 | AQP1 (0.38) | AQP1KDM4EALDH1A1MAPTS1PR4 | |
| SCHEMBL4220746 | 0.79 | AQP1 (0.60) | AQP1EZH2KDM4EALDH1A1MAPT | |
| SCHEMBL5606024 | 0.78 | AQP1 (0.37) | AQP1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL4220770 | 0.77 | AQP1 (0.49) | AQP1EZH2ALDH1A1S1PR4 | |
| SCHEMBL4220767 | 0.75 | AQP1 (0.64) | AQP1EZH2KDM4EALDH1A1MAPT | |
| SCHEMBL4790052 | 0.75 | AQP1 (0.44) | AQP1EZH2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |