Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 9/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732815 | 0.85 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL735273 | 0.85 | PIK3CG (0.69) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL734098 | 0.81 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL369837 | 0.81 | PIK3CG (0.77) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL735269 | 0.79 | PIK3CG (0.59) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL1300328 | 0.76 | PIK3CG (0.64) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL12105287 | 0.76 | PIK3CG (0.64) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL5607199 | 0.75 | PIK3CD (0.35) | PIK3CGPIK3CDPIK3CBABL1RAD52 | |
| SCHEMBL1497355 | 0.75 | PIK3CG (0.62) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 | |
| SCHEMBL19198778 | 0.75 | PIK3CG (0.62) | PIK3CGPIK3CDPIK3CBALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |