Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLR1A | O95602 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | LYN | P07948 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999854 | 0.90 | NPC1 (0.39) | ALDH1A1SMN1; SMN2KMT2AMAPTHPGD | |
| SCHEMBL2001500 | 0.89 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL2001982 | 0.89 | POLR1A (0.40) | POLR1AALDH1A1KDM4EMAPTADORA1 | |
| SCHEMBL2000585 | 0.81 | SMN1; SMN2 (0.42) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL1997921 | 0.81 | CDC25B (0.44) | ALDH1A1SMN1; SMN2KMT2AKDM4ETP53 | |
| SCHEMBL1995464 | 0.79 | KMT2A (0.46) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL2001626 | 0.78 | TRPV1 (0.39) | ALDH1A1SMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL2000588 | 0.78 | TRPV1 (0.38) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL1998635 | 0.77 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KMT2ATP53MAPT | |
| SCHEMBL1999230 | 0.75 | AURKA (0.42) | ALDH1A1SMN1; SMN2KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |