Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 7/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613981 | 0.90 | POLB (0.47) | POLBRAB9ANPC1TP53LMNA | |
| SCHEMBL3487587 | 0.83 | NR1H2 (0.51) | POLBL3MBTL1MAPTNR1H2NR1H3 | |
| SCHEMBL3486726 | 0.80 | CA12 (0.41) | TP53LMNASMN1; SMN2MAPTNR1H2 | |
| SCHEMBL3487073 | 0.80 | AR (0.47) | RAB9ANPC1SMN1; SMN2MAPTNR1H2 | |
| SCHEMBL3488251 | 0.76 | CA12 (0.44) | SMN1; SMN2MAPTNR1H2NR1H3ALDH1A1 | |
| SCHEMBL5606886 | 0.76 | PLK1 (0.33) | TP53MAPTNR1H2NR1H3ALDH1A1 | |
| SCHEMBL3487580 | 0.72 | NR1H2 (0.54) | POLBRAB9ANPC1SMN1; SMN2MAPT | |
| SCHEMBL19128357 | 0.71 | LTA4H (0.41) | POLBCHRM5RAB9ANPC1MAPT | |
| SCHEMBL5606877 | 0.69 | NR1H2 (0.38) | CHRM4POLBRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3488399 | 0.69 | NR1H2 (0.55) | POLBRAB9ANPC1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838686-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006073363-A1 | DERIVATIVES OF ISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDES AS LIVER X RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2006-07-13 | — | — | WO | disclosed |