Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 16/20 | 0.50 |
| ▸ | PIK3R1 | P27986 | 8/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5607724 | 0.97 | PIK3CD (0.51) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5606808 | 0.95 | PIK3CD (0.51) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5606851 | 0.91 | PIK3CD (0.56) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5606919 | 0.90 | PIK3CD (0.52) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5607763 | 0.90 | PIK3CD (0.47) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5607774 | 0.90 | PIK3CD (0.49) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL2328978 | 0.90 | PIK3CG (0.49) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL3209289 | 0.89 | PIK3CD (0.53) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5607273 | 0.88 | PIK3CD (0.43) | PIK3CDPIK3R1PIK3CGPIK3CBPIK3CA | |
| SCHEMBL5608379 | 0.87 | ALDH1A1 (0.48) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | claimed |
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |