SCHEMBL5607466

SCHEMBL5607466

CC(=O)OC12CC3(OC(C)=O)CC(OC(C)=O)(C1)CC(C(=O)O)(C2)C3

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GRM1 Q13255 2/20 0.34
ALDH1A1 P00352 1/20 0.33
TSHR P16473 1/20 0.33
EP300 Q09472 1/20 0.31
HIF1A Q16665 1/20 0.31
CREBBP Q92793 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11062782 0.85 ALDH1A1 (0.37) ALDH1A1TSHREP300HIF1ACREBBP
SCHEMBL5607904 0.81 ALDH1A1 (0.36) ALDH1A1EP300HIF1ACREBBP
SCHEMBL5607821 0.76 ALDH1A1 (0.30) ALDH1A1TSHR
SCHEMBL1734908 0.75 ALDH1A1 (0.37) GRM1ALDH1A1TSHR
SCHEMBL5607877 0.75 ALDH1A1 (0.49) ALDH1A1
SCHEMBL5608491 0.74
SCHEMBL22234943 0.73 GRM1 (0.38) GRM1
SCHEMBL5608899 0.71 ALDH1A1 (0.30) ALDH1A1TSHR
SCHEMBL16039163 0.71 ALDH1A1 (0.30) ALDH1A1TSHR
SCHEMBL5607557 0.70 EP300 (0.35) EP300HIF1ACREBBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE39744-E1 Adamantane derivatives and process for producing them DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2007-07-24 US disclosed
US-6392104-B1 CHEMICAL INTERMEDIATES FOR DRUGS, AGRICULTURE DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 2002-05-21 US disclosed
EP-0927711-A1 ADAMANTANE DERIVATIVES AND PROCESS FOR PRODUCING THEM Daicel Chemical Industries, Ltd. (JP) 1999-07-07 EP disclosed