Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5608379 | 0.94 | ALDH1A1 (0.48) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL5606945 | 0.91 | PIK3CD (0.52) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL5606274 | 0.91 | PIK3CD (0.44) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL6273888 | 0.90 | MAPT (0.60) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL2432095 | 0.89 | PIK3CD (0.41) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL2323929 | 0.89 | PIK3CD (0.51) | ALDH1A1HSD17B10RXFP1PIK3CDHTT | |
| SCHEMBL5607282 | 0.89 | PIK3CD (0.41) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL5607462 | 0.88 | PDE7A (0.42) | ALDH1A1HSD17B10RXFP1MAPTPIK3CD | |
| SCHEMBL14993340 | 0.87 | PIK3CD (0.51) | PIK3CD | |
| SCHEMBL5606978 | 0.87 | PIK3CG (0.51) | PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | claimed |
| EP-1750715-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005120511-A1 | METHODS FOR TREATING MAST CELL DISORDERS | ICOS CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |