Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL773361 | 0.85 | LCK (0.59) | RAB9AALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL19229754 | 0.83 | ALDH1A1 (0.47) | RAB9AALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL774683 | 0.80 | LCK (0.52) | RAB9AALDH1A1NPC1SMN1; SMN2POLB | |
| SCHEMBL774205 | 0.75 | MAPT (0.81) | RAB9AALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL4606198 | 0.74 | ALDH1A1 (0.63) | RAB9AALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL774466 | 0.74 | LCK (0.71) | RAB9ANPC1MAPT | |
| SCHEMBL4393473 | 0.73 | RXFP1 (0.53) | RAB9AALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL3580881 | 0.73 | POLB (0.63) | RAB9AALDH1A1NPC1SMN1; SMN2HPGD | |
| SCHEMBL19229755 | 0.73 | HTR2C (0.42) | RAB9ANPC1SMN1; SMN2HPGDKDM4E | |
| SCHEMBL5607983 | 0.72 | CHRNA7 (0.60) | RAB9AALDH1A1NPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758564-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | Brystol-Myers Squibb Company (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005094376-A2 | SYNERGISTIC METHODS AND COMPOSITIONS FOR TREATING CANCER | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-10-13 | — | — | WO | disclosed |