Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997694 | 0.94 | ALDH1A1 (0.35) | TRPV1POLBALDH1A1KDM4ERAB9A | |
| SCHEMBL1994456 | 0.92 | KDM4C (0.36) | POLBTSHRSMN1; SMN2KMT2ALMNA | |
| SCHEMBL5607826 | 0.88 | TRPV1 (0.47) | TRPV1POLBKDM4ETSHRHSD17B10 | |
| SCHEMBL5607679 | 0.85 | PDE4B (0.36) | TRPV1ALDH1A1KDM4ERAB9AMAPK8 | |
| SCHEMBL2001626 | 0.84 | TRPV1 (0.39) | TRPV1ALDH1A1TSHRSMN1; SMN2KMT2A | |
| SCHEMBL1997464 | 0.83 | TDP1 (0.40) | POLBALDH1A1KDM4ERAB9AHPGD | |
| SCHEMBL1997921 | 0.82 | CDC25B (0.44) | ALDH1A1KDM4EHPGDSMN1; SMN2KMT2A | |
| SCHEMBL2001436 | 0.82 | TRPV1 (0.42) | TRPV1ALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL1995971 | 0.81 | TRPV1 (0.43) | TRPV1ALDH1A1KDM4ERAB9AHSD17B10 | |
| SCHEMBL1996708 | 0.81 | TRPV1 (0.46) | TRPV1POLBALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758869-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123692-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |