Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 10/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5126566 | 0.84 | CHEK1 (0.66) | CHEK1KCNH2PLK1HASPIN | |
| SCHEMBL6513825 | 0.75 | CHEK1 (0.70) | CHEK1KCNH2PLK1 | |
| SCHEMBL6508464 | 0.75 | CHEK1 (0.53) | CHEK1KCNH2PLK1 | |
| SCHEMBL6515436 | 0.74 | CHEK1 (0.51) | CHEK1KCNH2PLK1 | |
| SCHEMBL5130032 | 0.74 | CHEK1 (0.68) | CHEK1KCNH2PLK1HASPIN | |
| SCHEMBL5132330 | 0.72 | CHEK1 (0.68) | CHEK1KCNH2PLK1HASPIN | |
| SCHEMBL6507976 | 0.72 | CHEK1 (0.53) | CHEK1KCNH2PLK1HASPIN | |
| SCHEMBL6522871 | 0.68 | CHEK1 (0.51) | CHEK1KCNH2PLK1 | |
| SCHEMBL6514910 | 0.67 | CHEK1 (0.49) | CHEK1PLK1 | |
| SCHEMBL5132237 | 0.66 | CHEK1 (0.69) | CHEK1KCNH2HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835918-A2 | INHIBITORS OF CHECKPOINT KINASES | Merck & Co., Inc. (US) | 2007-09-26 | — | — | EP | claimed |
| WO-2006074281-A2 | INHIBITORS OF CHECKPOINT KINASES | MERCK & CO., INC. (US) | 2006-07-13 | — | — | WO | claimed |