Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 4/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6507976 | 0.97 | CHEK1 (0.53) | CHEK1PIK3R1PIK3CAKCNH2PLK1 | |
| SCHEMBL6522871 | 0.93 | CHEK1 (0.51) | CHEK1PIK3R1PIK3CAKCNH2PLK1 | |
| SCHEMBL6513825 | 0.87 | CHEK1 (0.70) | CHEK1KCNH2PLK1CNR2MAPK8 | |
| SCHEMBL6508143 | 0.86 | PIK3R1 (0.43) | CHEK1PIK3R1PIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL6515436 | 0.84 | CHEK1 (0.51) | CHEK1KCNH2PLK1ALDH1A1LMNA | |
| SCHEMBL6513337 | 0.83 | PIK3R1 (0.45) | CHEK1PIK3R1PIK3CAALDH1A1SMN1; SMN2 | |
| SCHEMBL6515579 | 0.83 | PIK3R1 (0.43) | CHEK1PIK3R1PIK3CAKCNH2PLK1 | |
| SCHEMBL6517619 | 0.82 | CHEK1 (0.77) | CHEK1PIK3R1PIK3CAKCNH2PLK1 | |
| SCHEMBL6514168 | 0.79 | PLK1 (0.45) | PIK3R1PIK3CAPLK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6522395 | 0.79 | PLK1 (0.45) | PIK3R1PIK3CAPLK1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-11-03 | — | — | US | disclosed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050245563-A1 | Chk-1 inhibitors | CHKA, CHKB, CHEK1 | CHEK1 3/4885PIK3R1 439/4885PIK3CA 409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.