Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147336 | 0.92 | P2RX7 (0.61) | P2RX7MEN1KMT2A | |
| SCHEMBL4141508 | 0.90 | P2RX7 (0.66) | P2RX7MEN1KMT2A | |
| SCHEMBL4145623 | 0.89 | P2RX7 (0.58) | P2RX7MEN1KMT2A | |
| SCHEMBL3005979 | 0.88 | P2RX7 (0.71) | P2RX7 | |
| SCHEMBL5608896 | 0.87 | P2RX7 (0.51) | P2RX7GRM2 | |
| SCHEMBL4141994 | 0.86 | P2RX7 (0.59) | P2RX7 | |
| SCHEMBL4147712 | 0.85 | P2RX7 (0.65) | P2RX7 | |
| SCHEMBL4133030 | 0.84 | P2RX7 (0.66) | P2RX7 | |
| SCHEMBL4145373 | 0.84 | P2RX7 (0.65) | P2RX7MEN1KMT2A | |
| SCHEMBL13243987 | 0.83 | P2RX7 (0.64) | P2RX7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865774-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2006102588-A1 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2006-09-28 | — | — | WO | claimed |