SCHEMBL5609246

SCHEMBL5609246

N#Cc1ccc(CCCCCCN)cc1

nearest known ligand 0.68

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.61
HSD17B10 Q99714 1/20 0.61
LOXL2 Q9Y4K0 2/20 0.57
MAOA P21397 2/20 0.52
HRH1 P35367 4/20 0.52
KCNJ1 P48048 1/20 0.47
KCNH2 Q12809 1/20 0.47
HTR2A P28223 2/20 0.47
CYP2A6 P11509 1/20 0.47
IDO1 P14902 2/20 0.42
MAOB P27338 1/20 0.41
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA4 P22748 1/20 0.40
CA9 Q16790 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7387511 1.00 TSHR (0.61) TSHRHSD17B10LOXL2MAOAHRH1
SCHEMBL7427458 0.98 LOXL2 (0.59) TSHRHSD17B10LOXL2MAOAHRH1
Hydrochloric Acid SCHEMBL7415902 0.96 LOXL2 (0.57) TSHRHSD17B10LOXL2MAOAHRH1
SCHEMBL4949211 0.92 LOXL2 (0.61) TSHRHSD17B10LOXL2MAOAHRH1
Hydrochloric Acid SCHEMBL7418452 0.90 LOXL2 (0.59) TSHRHSD17B10LOXL2MAOAKCNJ1
SCHEMBL10569117 0.89 TSHR (0.71) TSHRHSD17B10LOXL2MAOAKCNJ1
SCHEMBL16582463 0.89 TSHR (0.71) TSHRHSD17B10LOXL2MAOAKCNJ1
SCHEMBL16582531 0.89 TSHR (0.71) TSHRHSD17B10LOXL2MAOAKCNJ1
SCHEMBL10569888 0.87 TSHR (0.68) TSHRHSD17B10LOXL2MAOAKCNJ1
SCHEMBL16603419 0.83 TSHR (0.82) TSHRHSD17B10LOXL2MAOAKCNJ1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1354887-B1 Ligands for metals and improved metal-catalyzed processes based thereon MASSACHUSETTS INST TECHNOLOGY (US) 2007-04-25 EP disclosed
EP-1097158-B1 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INST TECHNOLOGY (US) 2006-01-25 EP disclosed
EP-1354887-A1 Ligands for metals and improved metal-catalyzed processes based thereon Massachusetts Insitute of Technology (US) 2003-10-22 EP disclosed
EP-1097158-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2001-05-09 EP disclosed
WO-2000002887-A2 LIGANDS FOR METALS AND METAL-CATALYZED PROCESSES MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2000-01-20 WO disclosed