Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NEK2 | P51955 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4097357 | 0.89 | KDM4E (0.42) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4110344 | 0.88 | NEK2 (0.45) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4103864 | 0.87 | KDM4E (0.40) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4098866 | 0.87 | KDM4E (0.40) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4098179 | 0.86 | NEK2 (0.39) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4104992 | 0.85 | NEK2 (0.39) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4099757 | 0.85 | MAPT (0.46) | KDM4ENEK2LMNAMAPTMAPK1 | |
| SCHEMBL4114821 | 0.81 | LMNA (0.41) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL4099712 | 0.80 | MPL (0.42) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL5448530 | 0.79 | KDM4E (0.41) | KDM4ENEK2LMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006073361-A9 | NOVEL PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2007-08-02 | — | — | WO | disclosed |