Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Guanidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1133839 | 0.92 | PDE4A (0.50) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL5173596 | 0.90 | PDE4A (0.48) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| Malonic Acid SCHEMBL17966082 | 0.85 | PDE4A (0.44) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL6550889 | 0.78 | PDE4A (0.42) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL3952432 | 0.78 | PDE4A (0.42) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL6498093 | 0.77 | PDE4A (0.46) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL5559507 | 0.75 | LMNA (0.48) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL3899113 | 0.75 | LMNA (0.48) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL11210752 | 0.75 | LMNA (0.48) | USP2SLCO1B1PDE4ALMNAL3MBTL1 | |
| SCHEMBL4734230 | 0.75 | LMNA (0.53) | USP2SLCO1B1PDE4ALMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1417064-A4 | LUBRICANT SYSTEM FOR USE IN POWDERED METALS | APEX ADVANCED TECHNOLOGIES LLC (US) | 2006-12-20 | — | — | EP | claimed |
| US-20040175286-A1 | Lubricant system for use in powdered metals | APEX ADVANCED TECHNOLOGIES, LLC | 2004-09-09 | — | — | US | claimed |
| EP-1417064-A1 | LUBRICANT SYSTEM FOR USE IN POWDERED METALS | Apex Advanced Technologies, LLC (US) | 2004-05-12 | — | — | EP | claimed |
| US-20040077508-A1 | Lubricant system for use in powdered metals | APEX ADVANCED TECHNOLOGIES, LLC | 2004-04-22 | — | — | US | claimed |
| US-6679935-B2 | PRESSURIZING A SOLID LUBRICANT AND CONVERTING TO A LIQUID PHASE; USING IN MOLDING METAL POWDER OR PRESSING CERAMIC POWDER | APEX ADVANCED TECHNOLOGIES, LLC | 2004-01-20 | — | — | US | claimed |
| US-20030109388-A1 | Lubricant system for use in powdered metals | JOHNSON ELECTRIC NORTH AMERICA, INC. | 2003-06-12 | — | — | US | claimed |
| WO-2003015962-A1 | LUBRICANT SYSTEM FOR USE IN POWDERED METALS | APEX ADVANCED TECHNOLOGIES, LLC (US) | 2003-02-27 | — | — | WO | claimed |
| US-7264646-B2 | Lubricant system for use in powdered metals | APEX ADVANCED TECHNOLOGIES, LLC (US) | 2007-09-04 | — | — | US | disclosed |
| EP-1417064-A4 | LUBRICANT SYSTEM FOR USE IN POWDERED METALS | APEX ADVANCED TECHNOLOGIES LLC (US) | 2006-12-20 | — | — | EP | disclosed |
| US-20040175286-A1 | Lubricant system for use in powdered metals | APEX ADVANCED TECHNOLOGIES, LLC | 2004-09-09 | — | — | US | disclosed |
| EP-1417064-A1 | LUBRICANT SYSTEM FOR USE IN POWDERED METALS | Apex Advanced Technologies, LLC (US) | 2004-05-12 | — | — | EP | disclosed |
| US-20040077508-A1 | Lubricant system for use in powdered metals | APEX ADVANCED TECHNOLOGIES, LLC | 2004-04-22 | — | — | US | disclosed |
| US-6679935-B2 | PRESSURIZING A SOLID LUBRICANT AND CONVERTING TO A LIQUID PHASE; USING IN MOLDING METAL POWDER OR PRESSING CERAMIC POWDER | APEX ADVANCED TECHNOLOGIES, LLC | 2004-01-20 | — | — | US | disclosed |
| US-20030109388-A1 | Lubricant system for use in powdered metals | JOHNSON ELECTRIC NORTH AMERICA, INC. | 2003-06-12 | — | — | US | disclosed |
| WO-2003015962-A1 | LUBRICANT SYSTEM FOR USE IN POWDERED METALS | APEX ADVANCED TECHNOLOGIES, LLC (US) | 2003-02-27 | — | — | WO | disclosed |