Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxyphenbutazone Anhydrous. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 2/20 | 0.92 |
| ▸ | LMNA | P02545 | 3/20 | 0.92 |
| ▸ | RAB9A | P51151 | 3/20 | 0.92 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.92 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.92 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.92 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.92 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.92 |
| ▸ | TP53 | P04637 | 1/20 | 0.92 |
| ▸ | MAPT | P10636 | 1/20 | 0.92 |
| ▸ | HPGD | P15428 | 1/20 | 0.92 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.92 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 6/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxyphenbutazone Anhydrous SCHEMBL5316370 | 0.96 | LMNA (1.00) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25857 | 0.96 | LMNA (1.00) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL11337449 | 0.96 | LMNA (1.00) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25856 | 0.96 | LMNA (1.00) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL1263248 | 0.94 | LMNA (0.97) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL2525061 | 0.94 | LMNA (0.97) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL25854 | 0.94 | LMNA (0.97) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL3182776 | 0.94 | LMNA (0.97) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL1263243 | 0.93 | LMNA (0.94) | LMNARAB9AALDH1A1CYP3A4PTGS1 | |
| Oxyphenbutazone Anhydrous SCHEMBL28278628 | 0.93 | LMNA (0.94) | LMNARAB9AALDH1A1CYP3A4PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200040-B8 | TWO-COMPONENT COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE | IND E COM DE COSMETICOS NATURA (BR) | 2006-09-13 | — | — | EP | claimed |
| EP-1200040-A1 | TWO-COMPONENT COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE | Industria e Comercio de Comesticos Natura Ltda (BR) | 2002-05-02 | — | — | EP | claimed |
| WO-2001005357-A1 | TWO-COMPONENT COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE | Indústria e Comércio de Cosméticos Natura Ltda. (BR) | 2001-01-25 | — | — | WO | claimed |
| EP-2666517-B1 | Anticaries formulation | QUATTROTI DENTECH S R L (IT) | 2016-07-13 | — | — | EP | disclosed |
| EP-2666517-A1 | Anticaries formulation | Brux S.R.L. (IT) | 2013-11-27 | — | — | EP | disclosed |
| EP-1491566-B1 | Curable epoxy resin composition, and process for the production of shaped articles therefrom | ABB TECHNOLOGY LTD (CH) | 2007-02-28 | — | — | EP | disclosed |
| EP-1200040-B8 | TWO-COMPONENT COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE | IND E COM DE COSMETICOS NATURA (BR) | 2006-09-13 | — | — | EP | disclosed |
| US-20050004270-A1 | Curable epoxy resin composition, fabrication process using the same and shaped articles obtained therefrom | ABB T & D TECHNOLOGY LTD. (CH) | 2005-01-06 | — | — | US | disclosed |
| EP-1200040-A1 | TWO-COMPONENT COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE | Industria e Comercio de Comesticos Natura Ltda (BR) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005357-A1 | TWO-COMPONENT COMPOSITION FOR COSMETIC OR PHARMACEUTICAL USE | Indústria e Comércio de Cosméticos Natura Ltda. (BR) | 2001-01-25 | — | — | WO | disclosed |