Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | HSD17B2 | P37059 | 14/20 | 0.64 |
| ▸ | HSD17B1 | P14061 | 11/20 | 0.64 |
| ▸ | IKBKB | O14920 | 3/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2247416 | 0.87 | HDAC6 (0.72) | HDAC6HSD17B2HSD17B1 | |
| SCHEMBL5605133 | 0.85 | EPHX2 (0.61) | HDAC6HSD17B2HSD17B1IKBKBEPHX2 | |
| SCHEMBL12663202 | 0.84 | HDAC6 (0.69) | HDAC6HSD17B2HSD17B1 | |
| SCHEMBL23779 | 0.83 | HSD17B2 (0.67) | HDAC6HSD17B2HSD17B1 | |
| SCHEMBL3098643 | 0.83 | HDAC6 (1.00) | HDAC6HSD17B2HSD17B1 | |
| SCHEMBL23361 | 0.82 | HDAC6 (0.66) | HDAC6HSD17B2HSD17B1 | |
| SCHEMBL18832307 | 0.81 | HDAC6 (0.64) | HDAC6HSD17B2HSD17B1 | |
| SCHEMBL1181635 | 0.81 | CYP1A1 (0.67) | HDAC6HSD17B2HSD17B1IKBKB | |
| SCHEMBL5605815 | 0.80 | HDAC6 (0.56) | HDAC6HSD17B2HSD17B1IKBKBPARP1 | |
| SCHEMBL1784939 | 0.80 | EPHX2 (0.52) | HDAC6HSD17B2HSD17B1IKBKBEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |