Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.56 |
| ▸ | IKBKB | O14920 | 3/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 11/20 | 0.52 |
| ▸ | HSD17B1 | P14061 | 9/20 | 0.52 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.52 |
| ▸ | TUBB | P07437 | 2/20 | 0.52 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.52 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.52 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.52 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.52 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.52 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.52 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.52 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.52 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.52 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.52 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.52 |
| ▸ | TUBB2B | Q9BVA1 | 2/20 | 0.52 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613367 | 0.80 | HDAC6 (0.71) | HDAC6IKBKBHSD17B2HSD17B1PARP1 | |
| SCHEMBL4093065 | 0.79 | IKBKB (0.76) | HDAC6IKBKBTUBB4ATUBBTUBA3C | |
| SCHEMBL1181635 | 0.78 | CYP1A1 (0.67) | HDAC6IKBKBHSD17B2HSD17B1CNR1 | |
| SCHEMBL5613224 | 0.77 | HPGDS (0.51) | HDAC6IKBKBHSD17B2HSD17B1 | |
| SCHEMBL4082306 | 0.76 | TUBB4A (0.66) | HDAC6IKBKBHSD17B2TUBB4ATUBB | |
| SCHEMBL2247416 | 0.75 | HDAC6 (0.72) | HDAC6HSD17B2HSD17B1PTPN1 | |
| SCHEMBL4081426 | 0.75 | MAPT (0.67) | HDAC6IKBKBTUBB4ATUBBTUBA3C | |
| SCHEMBL12093643 | 0.74 | HDAC6 (0.55) | HDAC6IKBKBHSD17B2HSD17B1CNR1 | |
| SCHEMBL9430000 | 0.74 | HDAC6 (0.55) | HDAC6IKBKBHSD17B2HSD17B1TUBB4A | |
| SCHEMBL7058517 | 0.74 | HDAC6 (0.49) | HDAC6IKBKBHSD17B2HSD17B1TUBB4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1545537-B1 | ALPHA-7 NICOTINIC RECEPTOR AGONISTS AND STATINS IN COMBINATION | ASTRAZENECA AB (SE) | 2007-04-04 | — | — | EP | claimed |