Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25660385 | 0.92 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1ALDH1A1TSHR | |
| SCHEMBL15648853 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1ALDH1A1HSD17B10TSHR | |
| SCHEMBL16147061 | 0.81 | SMN1; SMN2 (0.50) | SMN1; SMN2NPSR1ALDH1A1HSD17B10TSHR | |
| SCHEMBL22580151 | 0.79 | SMN1; SMN2 (0.49) | SMN1; SMN2NPSR1ALDH1A1HSD17B10TSHR | |
| SCHEMBL10759080 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2NPSR1ALDH1A1KMT2AEPHX2 | |
| SCHEMBL14086753 | 0.78 | SMN1; SMN2 (0.46) | SMN1; SMN2NPSR1ALDH1A1HSD17B10TSHR | |
| Carbamic Acid SCHEMBL27703082 | 0.77 | ALDH1A1 (0.47) | SMN1; SMN2NPSR1ALDH1A1HSD17B10TSHR | |
| SCHEMBL6679868 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2NPSR1ALDH1A1TSHRALOX15 | |
| SCHEMBL839163 | 0.76 | ALDH1A1 (0.56) | SMN1; SMN2NPSR1ALDH1A1TSHRALOX15 | |
| SCHEMBL16175794 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2NPSR1ALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1860942-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | Renovis, Inc. (US) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006102610-A2 | BICYCLOHETEROARYL COMPOUNDS AS P2X7 MODULATORS AND USES THEREOF | RENOVIS, INC. (US) | 2006-09-28 | — | — | WO | disclosed |