Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613988 | 0.99 | NPC1 (0.35) | NPC1RAB9AMEN1KMT2AKDM4E | |
| Hydrochloric Acid SCHEMBL5613700 | 0.98 | NPC1 (0.34) | NPC1RAB9AMEN1KMT2AKDM4E | |
| Sulfuric Acid SCHEMBL5613811 | 0.93 | NPC1 (0.36) | NPC1RAB9AKDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL5613766 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL3966923 | 0.77 | NPC1 (0.35) | NPC1RAB9A | |
| SCHEMBL5613793 | 0.75 | KDM4E (0.32) | NPC1RAB9AKDM4EL3MBTL1 | |
| SCHEMBL3591662 | 0.74 | KMT2A (0.48) | NPC1RAB9AMEN1KMT2AKDM4E | |
| SCHEMBL5613771 | 0.73 | KDM4E (0.33) | KDM4EL3MBTL1 | |
| SCHEMBL5613777 | 0.70 | KDM4E (0.32) | KDM4EL3MBTL1 | |
| SCHEMBL5809748 | 0.65 | CNR1 (0.40) | NPC1RAB9AMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1784403-A1 | PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Yuhan Corporation (KR) | 2007-05-16 | — | — | EP | claimed |
| WO-2006038773-A1 | PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2006-04-13 | — | — | WO | claimed |