Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | NNMT | P40261 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CCNH | P51946 | 1/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31508289 | 1.00 | MAPK1 (0.46) | MAPK1HPGDSPIK3C3RIPK1NNMT | |
| SCHEMBL30569172 | 0.84 | ALDH1A1 (0.51) | PIK3C3SMN1; SMN2HDAC6KDM4EALDH1A1 | |
| SCHEMBL1607825 | 0.84 | ALDH1A1 (0.51) | PIK3C3SMN1; SMN2HDAC6KDM4EALDH1A1 | |
| SCHEMBL12709594 | 0.83 | PIK3C3 (0.50) | PIK3C3SMN1; SMN2CDK8CDK7HDAC6 | |
| SCHEMBL31194336 | 0.83 | PIK3C3 (0.50) | PIK3C3SMN1; SMN2CDK8CDK7HDAC6 | |
| SCHEMBL4145595 | 0.82 | PIK3C3 (0.47) | PIK3C3SMN1; SMN2HDAC6KDM4EALDH1A1 | |
| SCHEMBL1608350 | 0.80 | HDAC6 (0.60) | PIK3C3SMN1; SMN2HDAC6HTTAPP | |
| SCHEMBL4410049 | 0.79 | PIK3C3 (0.44) | HPGDSPIK3C3SMN1; SMN2HDAC6KDM4E | |
| SCHEMBL2671386 | 0.79 | PIK3C3 (0.47) | MAPK1PIK3C3CDK8HDAC6KDM4E | |
| SCHEMBL20364680 | 0.79 | PIK3C3 (0.44) | PIK3C3SMN1; SMN2HDAC6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130054-A2 | HETEROARYL COMPOUNDS AS INHIBITORS OF IRAK4, COMPOSITIONS AND APPLICATIONS THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2023-07-06 | — | — | WO | disclosed |
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-1784403-A1 | PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | Yuhan Corporation (KR) | 2007-05-16 | — | — | EP | disclosed |
| WO-2006038773-A1 | PYRROLO[3,2-B]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF | YUHAN CORPORATION (KR) | 2006-04-13 | — | — | WO | disclosed |