Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOXM1 | Q08050 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ESRRA | P11474 | 8/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5617115 | 0.93 | ESRRA (0.42) | FOXM1PTPN1ALOX5ESRRACYP1A1 | |
| SCHEMBL5616931 | 0.92 | FOXM1 (0.43) | FOXM1PTPN1ALOX5ESRRACYP1A1 | |
| SCHEMBL5613962 | 0.89 | FOXM1 (0.41) | FOXM1PTPN1ALOX5ESRRACYP1A1 | |
| SCHEMBL5616853 | 0.88 | FOXM1 (0.45) | FOXM1PTPN1ALOX5ESRRACYP1A1 | |
| SCHEMBL5614007 | 0.87 | PTPN1 (0.45) | FOXM1PTPN1ALOX5ESRRACDK8 | |
| SCHEMBL5613843 | 0.86 | PTPN1 (0.43) | FOXM1PTPN1ALOX5ESRRASRD5A1 | |
| SCHEMBL2202068 | 0.86 | ESRRA (0.47) | FOXM1ESRRAMEN1KMT2A | |
| SCHEMBL5613817 | 0.85 | PTPN1 (0.44) | FOXM1PTPN1ALOX5ESRRASRD5A1 | |
| SCHEMBL5614020 | 0.84 | PTPN1 (0.41) | FOXM1PTPN1ALOX5ESRRASRD5A1 | |
| SCHEMBL5614097 | 0.82 | HPGD (0.43) | FOXM1PTPN1ALOX5ESRRASRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |