Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESRRA | P11474 | 9/20 | 0.42 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.35 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5613835 | 0.93 | FOXM1 (0.41) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL5616931 | 0.93 | FOXM1 (0.43) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL5613962 | 0.91 | FOXM1 (0.41) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL5616853 | 0.90 | FOXM1 (0.45) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL5614007 | 0.89 | PTPN1 (0.45) | ESRRAFOXM1PTPN1ALOX5 | |
| SCHEMBL5613843 | 0.88 | PTPN1 (0.43) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL5613817 | 0.87 | PTPN1 (0.44) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL5614020 | 0.86 | PTPN1 (0.41) | ESRRAFOXM1PTPN1ALOX5SRD5A1 | |
| SCHEMBL4152564 | 0.86 | ESRRA (0.54) | ESRRAFOXM1HPGDMEN1NPC1 | |
| SCHEMBL2197524 | 0.86 | ESRRA (0.54) | ESRRAFOXM1HPGDMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805154-A2 | PHARMACEUTICAL COMPOSITIONS | Exelixis, Inc. (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006047269-A2 | PHARMACEUTICAL COMPOSITIONS | EXELIXIS, INC. (US) | 2006-05-04 | — | — | WO | disclosed |