Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 9/20 | 0.56 |
| ▸ | GAK | O14976 | 2/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.34 |
| ▸ | STK17B | O94768 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5484245 | 0.88 | NOS1 (0.57) | NOS1GAKMAP4K1NEK2TGFBR1 | |
| SCHEMBL5614223 | 0.87 | NOS1 (0.55) | NOS1GAKMAP4K1NEK2MAP3K11 | |
| SCHEMBL5461863 | 0.84 | NOS1 (0.55) | NOS1GAKMAP4K1NEK2STK17B | |
| SCHEMBL5466207 | 0.84 | NOS1 (0.55) | NOS1GAKMAP4K1NEK2TGFBR1 | |
| SCHEMBL5472215 | 0.84 | NOS1 (0.56) | NOS1GAKMAP4K1NEK2TGFBR1 | |
| SCHEMBL5456950 | 0.84 | NOS1 (0.56) | NOS1GAKMAP4K1NEK2TGFBR1 | |
| SCHEMBL5606918 | 0.84 | NOS1 (0.65) | NOS1GAKMAP4K1NEK2TGFBR1 | |
| SCHEMBL5464257 | 0.83 | NOS1 (0.54) | NOS1GAKMAP4K1NEK2STK17B | |
| SCHEMBL5459267 | 0.83 | NOS1 (0.54) | NOS1GAKMAP4K1NEK2STK17B | |
| SCHEMBL5469941 | 0.83 | NOS1 (0.56) | NOS1GAKMAP4K1NEK2STK17B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673092-B1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA IP NV (BE) | 2007-08-15 | — | — | EP | claimed |
| EP-1673092-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA Bioscience nv (BE) | 2006-06-28 | — | — | EP | claimed |
| WO-2005039587-A1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA BIOSCIENCE NV (BE) | 2005-05-06 | — | — | WO | claimed |
| EP-1673092-B1 | HETEROCYCLE-SUBSTITUTED PTERIDINE DERIVATIVES AND THEIR USE IN THERAPY | 4 AZA IP NV (BE) | 2007-08-15 | — | — | EP | disclosed |