Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 5/20 | 0.69 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.69 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 2/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2391251 | 0.90 | RXRA (0.70) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL2390262 | 0.88 | RXRA (0.70) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL2389861 | 0.86 | RXRA (0.67) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL2389730 | 0.86 | RXRA (0.69) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL2390436 | 0.85 | RXRA (0.69) | RXRANR1H2NR1H3MAPTRXFP1 | |
| SCHEMBL2390386 | 0.85 | RXRA (0.73) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL14214290 | 0.85 | RXRA (0.81) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL2387822 | 0.85 | RXRA (0.79) | RXRANR1H2NR1H3ALDH1A1KMT2A | |
| SCHEMBL2387975 | 0.85 | RXRA (0.73) | RXRANR1H2NR1H3TNKSTNKS2 | |
| SCHEMBL2388112 | 0.85 | RXRA (0.68) | RXRANR1H2NR1H3ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773337-A2 | MODULATORS OF NUCLEAR RECEPTORS | Exelixis, Inc. (US) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006025979-A9 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS INC (US) | 2006-04-20 | — | — | WO | disclosed |
| WO-2006025979-A2 | MODULATORS OF NUCLEAR RECEPTORS | EXELIXIS, INC. (US) | 2006-03-09 | — | — | WO | disclosed |