Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.46 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1514427 | 1.00 | KDM4E (0.64) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| Hydrochloric Acid SCHEMBL1514615 | 0.99 | KDM4E (0.62) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL6697752 | 0.93 | KDM4E (0.69) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| Hydrochloric Acid SCHEMBL5223467 | 0.91 | KDM4E (0.67) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL3291180 | 0.85 | KDM4E (0.67) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL3288371 | 0.84 | KDM4E (0.62) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL3289763 | 0.82 | KDM4E (0.53) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL3290456 | 0.81 | KDM4E (0.58) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL19011668 | 0.81 | KDM4E (0.66) | KDM4ERECQLALDH1A1MAPTDRD2 | |
| SCHEMBL3288435 | 0.81 | KDM4E (0.55) | KDM4ERECQLALDH1A1MAPTDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805165-A1 | 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006044454-A1 | 1-(HETERO)ARYL-3-AMINO-PYROLLIDINE DERIVATIVES FOR USE AS MGLUR3 RECEPTOR ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2006-04-27 | — | — | WO | disclosed |