SCHEMBL5616486

SCHEMBL5616486

CCCc1nc2c(c(C)c(C)n3nnnc23)n1CCCON

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.30
TLR7 Q9NYK1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5616047 0.85 TLR7 (0.33) TLR7
SCHEMBL5616279 0.85
SCHEMBL5616060 0.85
SCHEMBL5616277 0.85
SCHEMBL4316570 0.84 PDE4A (0.32) TLR8TLR7
SCHEMBL4313859 0.84 TLR7 (0.33) TLR8TLR7
SCHEMBL5335318 0.83 PDE4A (0.32) TLR8TLR7
SCHEMBL4317790 0.82 PDE4A (0.34) TLR8TLR7
SCHEMBL5617166 0.81 TNF (0.39) TLR7
SCHEMBL4792410 0.80 TDP1 (0.40) TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8673932-B2 Oxime substituted imidazo-containing compounds 3M INNOVATIVE PROPERTIES COMPANY (US) 2014-03-18 US disclosed
US-20070066639-A1 Oxime substituted imidazoquinolines 3M INNOVATIVE PROPERTIES COMPANY 2007-03-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070066639-A1 Oxime substituted imidazoquinolines IFNG, IRF3, IL2 TLR8 139/4885TLR7 69/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.