Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.41 |
| ▸ | KDM4B | O94953 | 1/20 | 0.41 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LOX | P28300 | 4/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424549 | 0.87 | KDR (0.52) | ALDH1A1POLBMEN1KMT2ALMNA | |
| SCHEMBL5616773 | 0.75 | MEN1 (0.52) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL5617022 | 0.75 | MEN1 (0.49) | MEN1KMT2ALOXLOXL2KDR | |
| SCHEMBL5616830 | 0.74 | GRM5 (0.57) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL5743572 | 0.73 | RAF1 (0.51) | POLBMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL5616839 | 0.73 | KDR (0.62) | MEN1KMT2AMAPTTDP1NPC1 | |
| SCHEMBL5624323 | 0.72 | RAF1 (0.61) | POLBLMNACYP1A2CYP2D6CYP2C19 | |
| SCHEMBL5724122 | 0.72 | CYP1A2 (0.70) | ALDH1A1POLBMEN1KMT2ALMNA | |
| SCHEMBL5616841 | 0.72 | KDR (0.61) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL5741572 | 0.72 | KDR (0.41) | MEN1KMT2ALOXLOXL2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007523921-A | — | — | 2007-08-23 | — | — | JP | claimed |
| EP-1718614-A1 | PYRIDINAMIDE DERIVATIVE AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-11-08 | — | — | EP | claimed |
| WO-2005085202-A1 | PYRIDINAMIDE DERIVATIVE AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-09-15 | — | — | WO | claimed |