Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | FLT1 | P17948 | 2/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 2/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5425094 | 0.87 | KDR (0.49) | KDRFLT1 | |
| SCHEMBL5427755 | 0.76 | KDR (0.52) | KDR | |
| SCHEMBL5616773 | 0.74 | MEN1 (0.52) | KDRFLT1MEN1KMT2A | |
| SCHEMBL5616830 | 0.74 | GRM5 (0.57) | KDRFLT1GRM5LOXLOXL2 | |
| SCHEMBL5743572 | 0.72 | RAF1 (0.51) | MEN1KMT2A | |
| SCHEMBL5616839 | 0.72 | KDR (0.62) | KDRLOXLOXL2MEN1CASP3 | |
| SCHEMBL5624323 | 0.72 | RAF1 (0.61) | KDR | |
| SCHEMBL5616825 | 0.72 | ALDH1A1 (0.48) | KDRLOXLOXL2MEN1KMT2A | |
| SCHEMBL5616841 | 0.71 | KDR (0.61) | KDRFLT1MEN1KMT2A | |
| SCHEMBL5616850 | 0.71 | GRM5 (0.49) | KDRGRM5LOXLOXL2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1718614-A1 | PYRIDINAMIDE DERIVATIVE AS KINASE INHIBITORS | MERCK PATENT GmbH (DE) | 2006-11-08 | — | — | EP | disclosed |
| WO-2005085202-A1 | PYRIDINAMIDE DERIVATIVE AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2005-09-15 | — | — | WO | disclosed |