Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.61 |
| ▸ | CCR4 | P51679 | 19/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5727669 | 0.93 | CCR5 (0.53) | CCR5CCR4 | |
| SCHEMBL4683809 | 0.89 | CCR5 (0.75) | CCR5CCR4 | |
| SCHEMBL4681259 | 0.89 | CCR4 (0.74) | CCR4 | |
| SCHEMBL4683826 | 0.82 | CCR4 (0.72) | CCR4 | |
| SCHEMBL4682187 | 0.80 | CCR4 (0.69) | CCR4 | |
| SCHEMBL14041061 | 0.80 | RXFP1 (0.61) | CCR4 | |
| SCHEMBL4681093 | 0.79 | CCR4 (0.65) | CCR4 | |
| SCHEMBL4681452 | 0.79 | CCR4 (0.67) | CCR4 | |
| SCHEMBL1731557 | 0.78 | CCR4 (0.78) | CCR4 | |
| SCHEMBL4680926 | 0.77 | CCR4 (0.65) | CCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007503432-A | — | — | 2007-02-22 | — | — | JP | claimed |
| EP-1660461-A1 | NOVEL CONDENSED N-PYRAZINYL-SULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES | AstraZeneca AB (SE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005021513-A1 | NOVEL CONDENSED N-PYRAZINYL-SULPHONAMIDES AND THEIR USE IN THE TREATMENT OF CHEMOKINE MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2005-03-10 | — | — | WO | claimed |