Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 9/20 | 0.46 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.39 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6291417 | 0.93 | PLK1 (0.45) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL6291820 | 0.92 | TP53 (0.45) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL5619875 | 0.91 | EGFR (0.45) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL6287805 | 0.90 | PLK1 (0.45) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL8362592 | 0.89 | BRAF (0.47) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL5619992 | 0.89 | RAF1 (0.52) | PLK1PLK3CDK2GAABRAF | |
| SCHEMBL5619399 | 0.89 | PLK1 (0.43) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL5619989 | 0.87 | PLK1 (0.41) | PLK1PLK3CDK2FLT3GAA | |
| SCHEMBL6291366 | 0.87 | EPHB4 (0.44) | PLK1PLK3CDK2GAATUBB4A | |
| SCHEMBL5619813 | 0.86 | BRAF (0.50) | PLK1BRAFMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202243-B2 | Substituted imidazotriazines | BAYER HEALTHCARE AG (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202243-B2 | Substituted imidazotriazines | BAYER HEALTHCARE AG (DE) | 2007-04-10 | — | — | US | disclosed |
| US-7202243-B2 | Substituted imidazotriazines | BAYER HEALTHCARE AG (DE) | 2007-04-10 | — | — | US | disclosed |
| US-20060166993-A1 | Substituted imidazotriazines | BAYER HEALTHCARE AG (DE) | 2006-07-27 | — | — | US | disclosed |
| EP-1599479-A1 | SUBSTITUTED IMIDAZOTRIAZINES | Bayer HealthCare AG (DE) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004005290-A1 | SUBSTITUTED IMIDAZOTRIAZINES | BAYER HEALTHCARE AG (DE) | 2004-01-15 | — | — | WO | disclosed |
| WO-2004005290-A1 | SUBSTITUTED IMIDAZOTRIAZINES | BAYER HEALTHCARE AG (DE) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060166993-A1 | Substituted imidazotriazines | SNCA, PARK7, TPMT | PLK1 3245/4885PLK3 3114/4885CDK2 449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.