Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5219104 | 0.88 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL475775 | 0.86 | MEN1 (0.56) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5219444 | 0.86 | MEN1 (0.56) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5221769 | 0.82 | POLB (0.48) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5221306 | 0.82 | ALDH1A1 (0.58) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5219191 | 0.81 | CA12 (0.53) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL2533613 | 0.81 | MEN1 (0.51) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5241791 | 0.81 | MEN1 (0.51) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5217876 | 0.80 | MEN1 (0.50) | KMT2AMEN1ALDH1A1HPGDCYP1A2 | |
| SCHEMBL5218738 | 0.80 | KMT2A (0.53) | KMT2AMEN1ALDH1A1HPGDCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160905-B2 | Hydroxyethylene compounds with Asp2 inhibitory activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-01-09 | — | — | US | disclosed |
| US-20050038028-A1 | Hydroxyethylene compounds with asp2 inhibitory activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-02-17 | — | — | US | disclosed |
| EP-1448516-A1 | HYDROXYETHYLENE COMPOUNDS WITH ASP2 INHIBITORY ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2004-08-25 | — | — | EP | disclosed |
| WO-2003045903-A1 | HYDROXYETHYLENE COMPOUNDS WITH ASP2 INHIBITORY ACTIVITY | SMITHKLINE BEECHAM P.L.C. (GB) | 2003-06-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038028-A1 | Hydroxyethylene compounds with asp2 inhibitory activity | BACE2, BACE1, PSEN2 | KMT2A 2372/4885MEN1 574/4885ALDH1A1 1269/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.