Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.48 |
| ▸ | CTSD | P07339 | 12/20 | 0.47 |
| ▸ | BACE2 | Q9Y5Z0 | 10/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5620638 | 1.00 | BACE1 (0.48) | BACE1CTSDBACE2CYP3A4APP | |
| SCHEMBL5620462 | 0.92 | BACE1 (0.47) | BACE1CTSDBACE2APP | |
| SCHEMBL5620459 | 0.92 | BACE1 (0.47) | BACE1CTSDBACE2APP | |
| SCHEMBL5620028 | 0.90 | BACE1 (0.44) | BACE1CTSDBACE2APP | |
| SCHEMBL5620024 | 0.90 | BACE1 (0.44) | BACE1CTSDBACE2APP | |
| SCHEMBL14641044 | 0.86 | BACE1 (0.43) | BACE1CTSDBACE2APP | |
| SCHEMBL14602363 | 0.85 | BACE1 (0.47) | BACE1CTSDBACE2 | |
| SCHEMBL8367166 | 0.84 | CTSD (0.54) | BACE1CTSDBACE2 | |
| SCHEMBL5619483 | 0.84 | CTSD (0.54) | BACE1CTSDBACE2 | |
| SCHEMBL5619490 | 0.84 | CTSD (0.54) | BACE1CTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7160905-B2 | Hydroxyethylene compounds with Asp2 inhibitory activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-01-09 | — | — | US | claimed |
| US-20050038028-A1 | Hydroxyethylene compounds with asp2 inhibitory activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-02-17 | — | — | US | claimed |
| US-7160905-B2 | Hydroxyethylene compounds with Asp2 inhibitory activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2007-01-09 | — | — | US | disclosed |
| US-20050038028-A1 | Hydroxyethylene compounds with asp2 inhibitory activity | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038028-A1 | Hydroxyethylene compounds with asp2 inhibitory activity | BACE2, BACE1, PSEN2 | BACE1 2/4885CTSD 607/4885BACE2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.