Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 15/20 | 0.53 |
| ▸ | ERBB2 | P04626 | 13/20 | 0.53 |
| ▸ | MMP2 | P08253 | 13/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.45 |
| ▸ | MMP12 | P39900 | 1/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.45 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175309 | 1.00 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2175314 | 1.00 | ADAM10 (0.53) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172019 | 0.93 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172021 | 0.93 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL5623049 | 0.93 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL5623036 | 0.93 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172174 | 0.93 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172180 | 0.93 | ADAM10 (0.57) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL5622904 | 0.92 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 | |
| SCHEMBL2172759 | 0.92 | ADAM10 (0.56) | ADAM10ERBB2MMP2MMP8MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509075-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |