Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 11/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | MARK2 | Q7KZI7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4658067 | 0.88 | BTK (0.41) | BTKMEN1KMT2ABRAFPIM1 | |
| SCHEMBL5622507 | 0.84 | BRAF (0.51) | BRAF | |
| SCHEMBL4761875 | 0.82 | BRAF (0.43) | BTKBRAFPIM1NTRK1MAPK13 | |
| SCHEMBL4831586 | 0.82 | EPHA2 (0.51) | RAB9ANPC1SMN1; SMN2BTKBRAF | |
| SCHEMBL5621460 | 0.82 | MAPK14 (0.46) | BTKBRAFPIM1MAPK13 | |
| SCHEMBL5816389 | 0.81 | CDKN1A (0.49) | ALDH1A1KDM4ESMN1; SMN2BTKHPGD | |
| SCHEMBL4791344 | 0.81 | BRAF (0.49) | RAB9ANPC1SMN1; SMN2BTKMEN1 | |
| SCHEMBL4655859 | 0.81 | HDAC1 (0.45) | BTKBRAFPIM1NTRK1MAPK13 | |
| SCHEMBL4657156 | 0.81 | RAB9A (0.48) | ALDH1A1RAB9ANPC1SMN1; SMN2BTK | |
| SCHEMBL4762381 | 0.81 | BRAF (0.47) | BTKBRAFPIM1NTRK1MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070219186-A1 | Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof | WYETH (US) | 2007-09-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070219186-A1 | Pyrazolo[1,5-A]pyrimidine derivatives and methods of use thereof | DPYD, TYMP, TYMS | ALDH1A1 253/4885GAA 2845/4885RAB9A 3300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.