Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 14/20 | 0.51 |
| ▸ | MMP2 | P08253 | 11/20 | 0.51 |
| ▸ | MMP3 | P08254 | 5/20 | 0.51 |
| ▸ | MMP9 | P14780 | 7/20 | 0.35 |
| ▸ | MMP1 | P03956 | 3/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.31 |
| ▸ | CTSC | P53634 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5038505 | 0.90 | ADAM10 (0.63) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038686 | 0.90 | ADAM10 (0.63) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL6024829 | 0.87 | ADAM10 (0.38) | ADAM10MMP2MMP3 | |
| SCHEMBL5622074 | 0.84 | ADAM10 (0.44) | ADAM10MMP2MMP3ERBB2 | |
| SCHEMBL5622068 | 0.83 | ADAM10 (0.42) | ADAM10MMP2MMP3CTSC | |
| SCHEMBL6023784 | 0.79 | ADAM10 (0.52) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038746 | 0.79 | ADAM10 (0.56) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5037490 | 0.78 | ADAM10 (0.52) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL5038481 | 0.78 | ADAM10 (0.52) | ADAM10MMP2MMP3MMP9MMP1 | |
| SCHEMBL2175334 | 0.78 | ADAM10 (0.81) | ADAM10MMP2MMP3MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509075-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | claimed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | claimed |
| EP-1678167-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | Incyte Corporation (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005037826-A1 | SUBSTITUTED CYCLIC HYDROXAMATES AS INHIBITORS OF MATRIX METALLOPROTEINASES | INCYTE CORPORATION (US) | 2005-04-28 | — | — | WO | disclosed |