Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5622144 | 1.00 | DRD2 (0.49) | DRD2DRD3KCNH2GRM7SIGMAR1 | |
| SCHEMBL5622302 | 1.00 | DRD2 (0.49) | DRD2DRD3KCNH2GRM7SIGMAR1 | |
| SCHEMBL5620557 | 0.90 | DRD2 (0.46) | DRD2DRD3KCNH2SIGMAR1ADORA2A | |
| SCHEMBL5622611 | 0.90 | DRD2 (0.46) | DRD2DRD3KCNH2SIGMAR1ADORA2A | |
| SCHEMBL14458480 | 0.90 | DRD2 (0.46) | DRD2DRD3KCNH2SIGMAR1ADORA2A | |
| SCHEMBL5621949 | 0.89 | DRD2 (0.50) | DRD2DRD3KCNH2SIGMAR1DRD4 | |
| SCHEMBL5623495 | 0.87 | DRD2 (0.43) | DRD2DRD3KCNH2SIGMAR1ADORA2A | |
| SCHEMBL14458604 | 0.87 | DRD2 (0.46) | DRD2DRD3KCNH2SIGMAR1ADORA2A | |
| SCHEMBL5620742 | 0.87 | DRD2 (0.43) | DRD2DRD3KCNH2SIGMAR1BCHE | |
| SCHEMBL5621104 | 0.87 | DRD2 (0.43) | DRD2DRD3KCNH2SIGMAR1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | claimed |
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
| US-20050239815-A1 | Tyrosine kinase inhibitors | KIM ANNETTE J | 2005-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | DRD2 1517/4885DRD3 1813/4885KCNH2 1155/4885 |
| US-20050239815-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | DRD2 1517/4885DRD3 1813/4885KCNH2 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.